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Article

Disruptions in gene interaction networks abolish host susceptibility to Trichostrongylus colubriformis infections in sheep.

PLoS neglected tropical diseases - 1 Aug 2025

Liu Fang, McNally Jody, Shao Jonathan, Ingham Aaron B, Hunt Peter W, Li Robert W

Abstract excerpt

The roundworm Trichostrongylus colubriformis is one of the most important parasites in sheep, impairing feed conversion and reducing growth. However, the molecular mechanism of host resistance to this important species remains elusive. In this study, we compared gene interaction networks manifested in the jejunum transcriptome between sheep bred for parasite resistance (RES) and susceptibility (SUS) in response...

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Topics

Animals
Sheep
Trichostrongylus
Sheep Diseases
Trichostrongylosis
Gene Regulatory Networks

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Transcriptome

Jejunum

Genetic Predisposition to Disease

Gene Expression Profiling

Host-Parasite Interactions

Source

Open in PubMed Open full text

Identifiers

PMID: 40811742
DOI: 10.1371/journal.pntd.0013399
PMCID: PMC12370191

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