A model of early-life interactions between the gut microbiome and adaptive immunity provides insights into the ontogeny of immune tolerance

Abstract excerpt

To achieve immune and microbial homeostasis during adulthood, the developing immune system must learn to identify which microbes to tolerate and which to defend against. How such 'immune education' unfolds remains a major knowledge gap. We address this gap by synthesizing existing literature to develop a mechanistic mathematical model representing the interplay between gut ecology and adaptive immunity in humans...

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