Training the Fetal Immune System Through Maternal Inflammation—A Layered Hygiene Hypothesis

Abstract excerpt

Over the last century, the alarming surge in allergy and autoimmune disease has led to the hypothesis that decreasing exposure to microbes, which has accompanied industrialization and modern life in the Western world, has fundamentally altered the immune response. In its current iteration, the 'hygiene hypothesis' suggests that reduced microbial exposures during early life restricts the production and...

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