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Article

On developmental programming of the immune system.

Trends in immunology - 1 Nov 2023

Hong Jun Young, Medzhitov Ruslan

Abstract excerpt

Early-life environmental exposures play a significant role in shaping long-lasting immune phenotypes and disease susceptibility. Nevertheless, comprehensive understanding of the developmental programming of immunity is limited. We propose that the vertebrate immune system contains durable programmable components established through early environmental interactions and maintained in a stable and homeostatic...

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PMID: 37852863
DOI: 10.1016/j.it.2023.09.004

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