Article
The Ability of Enzymes to Preserve Reactive Conformations During Enzyme-Catalyzed Reactions can be an Important Factor for Efficient Catalysis.
Chemistry (Weinheim an der Bergstrasse, Germany) - 1 Sept 2025
Yang Mingling, Deng Hao, Rahman Adua, Qian Ping, Guo Hong
Abstract excerpt
Determining strategies used by enzymes to achieve enormous rate enhancements has been a central goal in biochemical research. The abilities to form catalytic competent reactive conformations for enzyme-substrate complexes with well-positioned residues and to lower activation barriers through transition state (TS) stabilization are two accepted mechanisms. Enzymes might have evolved to possess other unrecognized...
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