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Cathepsin S regulates antitumor immunity through autophagic degradation of PD-L1 in colorectal cancer cells

12 Aug 2025

Abstract excerpt

Colorectal cancer (CRC) is a major contributor to cancer-related mortality worldwide, highlighting the need to overcome its immunosuppressive tumor microenvironment. Cathepsin S (CTSS), a cysteine protease essential for MHC class II antigen presentation, has an unclear role in CRC immunity. This study investigated the impact of CTSS on PD-L1 expression and T-cell function in CRC. CTSS expression was analyzed in...

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PMID: 40794185
DOI: 10.1007/s00262-025-04140-x

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