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Article

Cathepsin B Expression and Survival in Colon Cancer: Implications for Molecular Detection of Neoplasia

1 Nov 2010

Abstract excerpt

BACKGROUND AND AIMS: Proteases play a critical role in tumorigenesis and are upregulated in colorectal cancer and neoplastic polyps. In animal models, cathepsin B (CTSB)-activatable imaging agents show high enzyme activity within intestinal tumors. METHODS: We conducted a prospective cohort study of 558 men and women with colon cancer with tumors that were accessible for immunohistochemical assessment. We used...

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PMID: 20833970
DOI: 10.1158/1055-9965.epi-10-0529

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