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Prediction and therapeutic targeting of the tumor microenvironment-associated gene CTSK in gastric cancer

6 Nov 2023

Abstract excerpt

BACKGROUND: Cathepsin-K (CTSK) is overexpressed in Gastric cancer (GC) and the mechanism of its overexpression in GC is still unclear. The present work found CTSK as a potential predictive biomarker and immunotherapeutic target for GC based on the tumor microenvironment (TME). METHODS: From public databases, gene expression profiles and clinical data of GC were downloaded to analyze the distribution of stromal...

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PMID: 37930479
DOI: 10.1007/s12672-023-00821-0

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