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Article

SERPINB2 is a novel TGFβ-responsive lineage fate determinant of human bone marrow stromal cells.

Scientific reports - 7 Sept 2017

Elsafadi Mona, Manikandan Muthurangan, Atteya Muhammad, Abu Dawud Raed, Almalki Sami, Ali Kaimkhani Zahid, Aldahmash Abdullah, Alajez Nehad M, Alfayez Musaad, Kassem Moustapha, Mahmood Amer

Abstract excerpt

TGF-β1, a multifunctional regulator of cell growth and differentiation, is the most abundant bone matrix growth factor. During differentiation of human bone stromal cells (hBMSCs), which constitute bone marrow osteoblast (OS) and adipocyte (AD) progenitor cells, continuous TGF-β1 (10 ng/ml) treatment enhanced OS differentiation as evidenced by increased mineralised matrix production. Conversely, pulsed TGF-β1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28883483
DOI: 10.1038/s41598-017-10983-x
PMCID: PMC5589808

Genes

SERPINB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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