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Regulatory KIR + CD8 + T cells are elevated during human pregnancy

6 Aug 2025

Abstract excerpt

During pregnancy, immune responses must balance protection from infections with tolerance of the semiallogeneic fetus. However, the mechanisms regulating maternal-fetal tolerance remain poorly understood. Recently, we identified CD8 + T cells expressing inhibitory killer cell immunoglobulin-like receptors (KIRs) as a regulatory subset important for suppressing self-reactivity in human autoimmune and infectious...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40768597
DOI: 10.1126/scitranslmed.adm7697

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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