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Spatial metabolic and phenotypic characterization of the germ-free mouse model.

Annals of the New York Academy of Sciences - 1 Sept 2025

Adams Lauren, Hulme Heather, Dritsa Clio, Lynch Connor, Taylor Vicky, Rasid Orhan, Burchmore Richard, Goodwin Richard J A, Wall Daniel M

Abstract excerpt

The gut microbiome has been strongly linked to health and disease, exerting its systemic effects through host and bacterial molecules that disseminate from the intestine. Understanding how these molecules may contribute to, exacerbate, or even improve specific health conditions is a key mechanistic challenge in microbiome research. Using the germ-free mouse model, we used a spatial biology approach to map the...

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PMID: 40760821
DOI: 10.1111/nyas.70002
PMCID: PMC12448274

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