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Article

DNAJC13 localization to endosomes is opposed by its J domain and its disordered C-terminus.

Molecular biology of the cell - 1 Sept 2025

Adoff Hayden, Novy Brandon, Holland Emily, Lobingier Braden T

Abstract excerpt

Endosomes are a central sorting hub for membrane cargos. DNAJC13/RME-8 plays a critical role in endosomal trafficking by regulating the endosomal recycling and degradative pathways. DNAJC13 localizes to endosomes through its N-terminal Pleckstrin Homology (PH)-like domain, which binds endosomal phosphatidylinositol-3-phosphate (PI(3)P). However, little is known about how DNAJC13 localization is regulated. Here,...

Read the complete abstract on PubMed

Topics

Endosomes
Humans
Phosphatidylinositol Phosphates
Protein Transport
Protein Domains
HeLa Cells
HSP40 Heat-Shock Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Protein Binding

Mutation

Molecular Chaperones

HEK293 Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 40737286
DOI: 10.1091/mbc.E24-12-0575
PMCID: PMC12404652

Genes

DNAJC13
HPD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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