Article
Genome-wide gene by sleepiness interaction analysis for sleep apnea.
Sleep - 13 Jan 2026
Nagarajan Pavithra, Kurniansyah Nuzulul, Lee Jiwon, Gharib Sina A, Xu Yushan, Zhang Yiyan, Spitzer Brian, Faquih Tariq, Zhou Hufeng, Boerwinkle Eric, Chen Han, Gottlieb Daniel J, Guo Xiuqing, Heard-Costa Nancy L, Hidalgo Bertha A, Levy Daniel, Liu Peter Y, Mei Hao, Montalvan Rebecca, Mukherjee Sutapa, North Kari E, O'Connor George T, Palmer Lyle J, Patel Sanjay R, Psaty Bruce M, Purcell Shaun M, Raffield Laura M, Rich Stephen S, Rotter Jerome I, Saxena Richa, Smith Albert V, Stone Katie L, Zhu Xiaofeng, Cade Brian E, Sofer Tamar, Redline Susan, Wang Heming
Abstract excerpt
STUDY OBJECTIVES: Excessive daytime sleepiness (EDS), influenced by environmental and social-behavioral factors, is reported by a subset of patients with sleep apnea-a group that may be at elevated cardiovascular risk. However, it is unclear whether sleep apnea with and without EDS have distinct genetic underpinnings. In this study, we perform gene-by-EDS interaction analyses for apnea hypopnea index, a...
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