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Article

PALB2 mutations increase oncogenic properties of breast epithelial cells by enhancing JAM3 and PARVB expression.

Biochemical and biophysical research communications - 8 Sept 2025

Tuppurainen Hanna, Nätynki Marjut, Laurila Niina, Pylkäs Katri, Winqvist Robert, Peltoketo Hellevi

Abstract excerpt

High-risk genes, heterozygous pathogenic mutations of which predispose to familial breast cancers, typically encode factors securing a proper DNA damage response. PALB2 is one such major cellular factor that is needed for alleviation of genomic, replicative, and oxidative stresses. Thus, it has a crucial role in maintaining genomic integrity and protecting cells against cancer. While the malfunctions in DNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 40730089
DOI: 10.1016/j.bbrc.2025.152402

Genes

PALB2
JAM3
PARVB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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