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B- and T cell receptor sequencing elucidates characteristics of lymphocyte depletion by ocrelizumab

7 Jul 2025

Abstract excerpt

T cells was evident in highly expanded T-cell receptor beta chain and Vd2+ T-cell receptor delta chain clonotypes. Peripheral immunoglobulin heavy chain repertoires six months after initial depletion showed a bimodal patient distribution with either few B cells with high levels of somatic hypermutation, and comparatively high-sequence overlap with baseline samples, consistent with incomplete depletion of...

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PMID: 40727939
DOI: 10.1016/j.isci.2025.113068

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