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Essential role of miR-200c in regulating self-renewal of breast cancer stem cells and their counterparts of mammary epithelium

23 Sept 2015

Abstract excerpt

BACKGROUND: Breast cancer stem cells (BCSCs) have been reported as the origin of breast cancer and the radical cause of drug resistance, relapse and metastasis in breast cancer. BCSCs could be derived from mutated mammary epithelial stem cells (MaSCs). Therefore, comparing the molecular differences between BCSCs and MaSCs may clarify the mechanism underlying breast carcinogenesis and the targets for gene therapy....

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PMID: 26400441
DOI: 10.1186/s12885-015-1655-5

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