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Article

A rare likely pathogenic HLA-DRB1 variant with compromised immunity in severe COVID-19 patient and in-hospital mortality.

Personalized medicine - 1 Oct 2025

Mir Rashid, Alsayed Badr A, Fahad Ullah Mohammad

Abstract excerpt

The severity of COVID-19 disease can vary greatly, influenced by genetic factors and comorbid conditions that may increase mortality. This study has examined potential genetic influences on the disease for a young adult aged 36 years with T2DM-CAD multi-morbidity with severe COVID-19 disease and in-hospital mortality using whole-exome sequencing. The patient exhibited a constellation of severe symptoms and...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genetic Predisposition to Disease

Share to HLA-DRB1 Chains

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Source

Identifiers

PMID: 40704829
DOI: 10.1080/17410541.2025.2538424

Genes

CAD
IL23R
PAX6
PRKDC
RNF31
SLC37A4
TAP2
TCIRG1
TCN2
TPP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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