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Article

Histopathologic and molecular evidence of malignant potential in morules associated with gastrointestinal neoplasia.

Virchows Archiv : an international journal of pathology - 1 Apr 2026

Agostini-Vulaj Diana, Oltavi Zoltan N, Liao Xiaoyan

Abstract excerpt

Gastrointestinal (GI) adenomas with distinct solid cell clusters showing squamous or neuroendocrine differentiation are interchangeably termed as "squamoid morule (SM)" or "microcarcinoid (MC)." Though considered benign, their biogenesis and malignant potential remain contentious. We reviewed 39 cases of GI neoplasms with morules to characterize their histomorphology, immunoprofile, and molecular features. The...

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Identifiers

PMID: 40699319
DOI: 10.1007/s00428-025-04181-8

Genes

APC
CDX2
INSM1
KRAS
PIK3CA
SATB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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