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Article

IPPK-1 and IP6 contribute to ventral nerve cord assembly in C. elegans.

Developmental biology - 1 Oct 2025

Noblett Nathaniel, Roenspies Tony, Kirezi Chloe B, Stubbert Clover, Flibotte Stephane, Shah Pavak K, Colavita Antonio

Abstract excerpt

Inositol phosphates (IPs) are essential for the development and function of the nervous system. Loss-of-function studies, which demonstrate the importance of specific IP isomers, show their critical role in proper neural tube formation. In this study, we show that inositol pentakisphosphate 2-kinase (IPPK-1), the kinase that phosphorylates IP5 to generate IP6, is involved in assembling the ventral nerve cord...

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Identifiers

PMID: 40685063
DOI: 10.1016/j.ydbio.2025.07.007
PMCID: PMC13007942

Genes

IPPK

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