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Developing serum proteomics based prediction models of disease progression in ADPKD

19 Jul 2025

Abstract excerpt

Autosomal Dominant Polycystic Kidney Disease is the most common genetic cause of kidney failure. Outcome prediction is essential to guide therapeutic decisions. However, currently available models are of limited accuracy. We aimed to examine the potential of serum proteomics for improved risk stratification. Here we show that 29 proteins are significantly associated with yearly kidney function decline. Functional...

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PMID: 40681500
DOI: 10.1038/s41467-025-61887-8

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