Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Critical Role of Enhanced OXPHOS and Mitochondrial Hyperpolarization in Simulated Microgravity‐Induced Oocyte Maturation Arrest

18 Jul 2025

Abstract excerpt

Meiosis is essential for sexual reproduction, yet the impact of microgravity on oocyte maturation remains unclear, raising concerns for reproductive success in space environments. Here, it is examined the effects of simulated microgravity (SMG) on mouse oocytes and found that SMG impaired mitochondrial function, evidenced by elevated oxidative phosphorylation and mitochondrial membrane hyperpolarization,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Microtubule and mitosis dynamics
Share to Reproductive Biology and Fertility
Share to Spaceflight effects on biology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40679065
DOI: 10.1002/advs.202505570

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Critical Role of Enhanced OXPHOS and Mitochondrial Hyperpolarization in Simulated Microgravity‐Induced Oocyte Maturation ArrestPMID 40679065Read ↗

Mitochondria-targeted therapeutics, MitoQ and BGP-15, reverse aging-associated meiotic spindle defects in mouse and human oocytesSemantic proximity Read ↗

Acentriolar spindle assembly in mammalian female meiosis and the consequences of its perturbations on human reproductionSemantic proximity Read ↗

Vitrification-induced activation of lysosomal cathepsin B perturbs spindle assembly checkpoint function in mouse oocytesSemantic proximity Read ↗

Mitochondrial dysfunction in oocytes: implications for fertility and ageingSemantic proximity Read ↗

Molecular Mechanisms Responsible for Increased Vulnerability of the Ageing Oocyte to Oxidative DamageSemantic proximity Read ↗

Mitochondrial Ca2+ Overload Leads to Mitochondrial Oxidative Stress and Delayed Meiotic Resumption in Mouse OocytesSemantic proximity Read ↗

Maternal total sleep deprivation causes oxidative stress and mitochondrial dysfunction in oocytes associated with fertility decline in miceSemantic proximity Read ↗

Centrosome dynamics during mammalian oocyte maturation with a focus on meiotic spindle formationSemantic proximity Read ↗

Aging and oocyte competence: A molecular cell perspectiveSemantic proximity Read ↗

Reproductive Ageing: Metabolic contribution to age-related chromosome missegregation in mammalian oocytesSemantic proximity Read ↗

Control of mitochondrial integrity influences oocyte quality during reproductive agingSemantic proximity Read ↗

Positioning to get out of meiosis: the asymmetry of divisionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.