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Article

Functionally redundant forms of extended-spectrum beta-lactamases and aminoglycoside-modifying enzymes drive the evolution of two distinct multidrug resistance gene clusters in clinical populations of EXPEC

2018-07-12

Abstract excerpt

We evaluate the distribution of genetic markers for antibiotic resistance in 276 genomic sequences of Extraintestinal Pathogenic E. coli from two hospitals on the U.S. West coast. Plasmid-borne genes encoding drug-inactivating enzymes dominate the distribution of aminoglycoside and β -lactam resistance markers. These genes can be assigned based on their distribution to two mutually exclusive complementarity grou...

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Literature Corpus work
b2bfde29-18ee-5e08-931b-7aa02cf05296
DOI
10.1101/367938
Open publication

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