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NFATc1 facilitates hepatocellular carcinoma progression by regulating the senescence-associated secretory phenotype

10 Jul 2025

Abstract excerpt

The Nuclear Factor of Activated T-cells cytoplasmic 1 (NFATc1) is identified to be an oncogene in several human cancers. However, its specific role in HCC progression and the relevant mechanisms remain unclear. To investigate this, we analyzed NFATc1 expression in clinical HCC samples (n = 289) using RT-qPCR, Western blotting, and immunohistochemistry (IHC). In vitro assays assessed HCC cell proliferation,...

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PMID: 40640247
DOI: 10.1038/s41598-025-07585-3

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