Article
Over-expression of BCAT1, a c-Myc target gene, induces cell proliferation, migration and invasion in nasopharyngeal carcinoma.
Molecular cancer - 8 Jun 2013
Zhou Wen, Feng Xiangling, Ren Caiping, Jiang Xingjun, Liu Weidong, Huang Wei, Liu Zhihong, Li Zan, Zeng Liang, Wang Lei, Zhu Bin, Shi Jia, Liu Jie, Zhang Chang, Liu Yanyu, Yao Kaitai
Abstract excerpt
BACKGROUND: Nasopharyngeal carcinoma (NPC) is a common malignant tumor in southern China and Southeast Asia, but its molecular mechanisms of pathogenesis are poorly understood. Our previous work has demonstrated that BCAT1 mRNA is over expressed in NPC and knocking down its expression in 5-8F NPC cell line can potently inhibit cell cycle progression and cell proliferation. However, the mechanism of BCAT1...
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