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Article

Unveiling non-small cell lung cancer treatment effect heterogeneity: a comparative analysis of statistical methods.

Journal of the National Cancer Institute - 1 Oct 2025

Lavery Jessica A, Chen Yuan, Panageas Katherine S, Wang Yuanjia

Abstract excerpt

BACKGROUND: For patients with advanced non-small cell lung cancer lacking targetable genomic alterations, the impact of clinicogenomic characteristics on the effectiveness of combining chemotherapy with immunotherapy is unclear. METHODS: We evaluated 4 statistical methods for detecting heterogeneous treatment effects related to clinical factors, including programmed death-ligand 1 expression, tumor mutation...

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Identifiers

PMID: 40637678
DOI: 10.1093/jnci/djaf176
PMCID: PMC12505139

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