Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Whole-genome sequencing shows modulation of neurodegenerative genes by Withania somnifera in human SK-N-SH cells

25 Jun 2025

Abstract excerpt

Background Aging is driven by several primary and secondary hallmarks that manifest with age, of which neurodegenerative diseases are important manifestations. The ability to decelerate or reverse aging, and promote healthy aging, has garnered great interest in recent times. In traditional medicine, Withania somnifera (WS) or Ashwagandha has been recognized for its adaptogenic and rejuvenative effects. Methods To...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Phytochemicals and Medicinal Plants

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 40636521
DOI: 10.3389/fnmol.2025.1512727

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Whole-genome sequencing shows modulation of neurodegenerative genes by Withania somnifera in human SK-N-SH cellsPMID 40636521Read ↗

Withania somnifera (Ashwagandha) Improves Spatial Memory, Anxiety and Depressive-Like Behavior in the 5xFAD Mouse Model of Alzheimer’s DiseaseSemantic proximity Read ↗

A single-cell atlas of the human brain in Alzheimer’s disease and its implications for personalized drug repositioningSemantic proximity Read ↗

Bioactivated Glucoraphanin Improves Cell Survival, Upregulating Phospho-AKT, and Modulates Genes Involved in DNA Repair in an In Vitro Alzheimer’s Disease Model: A Network-Transcriptomic AnalysisSemantic proximity Read ↗

Impaired Pathways of Detoxification and Risk of Alzheimer’s Disease in Humans - Differential Gene Expression Studies via Gene Set Expression AnalysisSemantic proximity Read ↗

<i>Withania somnifera</i> showed neuroprotective effect and increase longevity in <i>Drosophila</i> Alzheimer’s disease modelSemantic proximity Read ↗

Agomelatine drives sex-specific neuroprotection and reduced pathology in rat and human Alzheimer’s modelsSemantic proximity Read ↗

Pathways to healing: Plants with therapeutic potential for neurodegenerative diseasesSemantic proximity Read ↗

Transcriptomic analysis of glutamate-induced HT22 neurotoxicity as a model for screening anti-Alzheimer’s drugsSemantic proximity Read ↗

Effect of the alcoholic extract of Ashwagandha leaves and its components on proliferation, migration, and differentiation of glioblastoma cells: Combinational approach for enhanced differentiationSemantic proximity Read ↗

Withania somnifera Extracts Promote Resilience against Age-Related and Stress-Induced Behavioral Phenotypes in Drosophila melanogaster; a Possible Role of Other Compounds besides Withanolides.Semantic proximity Read ↗

Transcriptome Network Biology Reveals the Neuroprotective Potential of Rosmarinic Acid Against Frontotemporal DementiaSemantic proximity Read ↗

Exploring bioactive natural products for treating neurodegenerative diseases: a computational network medicine approach targeting the estrogen signaling pathway in amyotrophic lateral sclerosis and Parkinson’s diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.