Article
Genetic risk-dependent brain markers of resilience to childhood Trauma.
Nature communications - 5 Jul 2025
Lu Han, Rolls Edmund T, Liu Hanjia, Stein Dan J, Sahakian Barbara J, Elliott Rebecca, Jia Tianye, Xie Chao, Xiang Shitong, Wang Nan, Banaschewski Tobias, Bokde Arun L W, Desrivières Sylvane, Flor Herta, Grigis Antoine, Garavan Hugh, Heinz Andreas, Brühl Rüdiger, Martinot Jean-Luc, Martinot Marie-Laure Paillère, Artiges Eric, Nees Frauke, Orfanos Dimitri Papadopoulos, Lemaitre Herve, Poustka Luise, Hohmann Sarah, Holz Nathalie, Fröhner Juliane H, Smolka Michael N, Vaidya Nilakshi, Walter Henrik, Whelan Robert, Schumann Gunter, Feng Jianfeng, Luo Qiang
Abstract excerpt
Resilience to developing emotional disorders is critical for adolescent mental health, especially following childhood trauma. Yet, brain markers of resilience remain poorly understood. By analyzing brain responses to angry faces in a large-scale longitudinal adolescent cohort (IMAGEN), we identified two functional networks located in the orbitofrontal and occipital regions. In girls with high genetic risks for...
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