Article
Global assessment of partial artemisinin resistance: multicenter trial across Kenya, Peru, and Thailand in patients with uncomplicated Plasmodium falciparum malaria.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 1 Oct 2025
Andagalu Ben, Smith Edward, Durand Salomon, Valdivia Hugo O, Onyango Irene, Spring Michele, Pattaraporn Vanachayangkul, Baldeviano G Christian, Majid Elazia, Sriwichai Sabaithip, Cummings James, Tapia Lorena, Akala Hosea, Gosi Panita, Cabezas Cesar, Juma Dennis, Wongararunkochakorn Saowaluk, Sihuincha Moises, Chaisatit Chaiyaporn, Chebon-Bore Lorna, Kuntawunginn Worachet, Halbach Alaina, Kodchakorn Chanikarn, Thamnurak Chatchadaporn, Praditpol Chantida, Saingam Piyaporn, Edgel Kimberly A, Saunders David, Cheruiyot Agnes, Chuang Ilin, Milgotina Ekaterina, Fernandes Paula, Lescano Andres G, Boonyalai Nonlawat, Kamau Edwin, Forshey Brett M, Cinkovich Stephanie, Bethell Delia, Jongsakul Krisada, Fukuda Mark
Abstract excerpt
OBJECTIVES: Artemisinin-resistant Plasmodium falciparum challenges the effectiveness of all artemisinin-based combination therapies. METHODS: We conducted a clinical study in Peru, Kenya, and Thailand between June 2013 and November 2015 in subjects treated with three standard doses of artesunate followed by two doses of mefloquine. The primary endpoint was parasite clearance half-life (PC1/2) during the 72-hour...
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