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Article

The nasal methylome as a biomarker of asthma and airway inflammation in children

12 Jul 2019

Abstract excerpt

The nasal cellular epigenome may serve as biomarker of airway disease and environmental response. Here we collect nasal swabs from the anterior nares of 547 children (mean-age 12.9 y), and measure DNA methylation (DNAm) with the Infinium MethylationEPIC BeadChip. We perform nasal Epigenome-Wide Association analyses (EWAS) of current asthma, allergen sensitization, allergic rhinitis, fractional exhaled nitric...

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PMID: 31300640
DOI: 10.1038/s41467-019-11058-3

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