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Article

Inhibition of autophagy enhances the antitumor efficacy of T/CAR T cell against neuroblastoma

3 Jul 2025

Abstract excerpt

Abstract Neuroblastoma (NB) is the most common extracranial solid tumor in children characterized by poor immune infiltration and resistance to adaptive immunity, contributing to its limited response to immunotherapy. A key mechanism underlying immune evasion in cancer is autophagy, a cellular process that plays many roles in cancer by supporting tumor survival and regulating immune interactions. In this study,...

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PMID: 40611330
DOI: 10.1186/s13046-025-03453-0

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