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USP14 regulates DNA damage repair by targeting RNF168-dependent ubiquitination

12 Jul 2018

Abstract excerpt

Recent reports have made important revelations, uncovering direct regulation of DNA damage response (DDR)-associated proteins and chromatin ubiquitination (Ubn) by macroautophagy/autophagy. Here, we report a previously unexplored connection between autophagy and DDR, via a deubiquitnase (DUB), USP14. Loss of autophagy in prostate cancer cells led to unrepaired DNA double-strand breaks (DSBs) as indicated by...

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PMID: 29995557
DOI: 10.1080/15548627.2018.1496877

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