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Article

Targeting USP11 may alleviate radiation-induced pulmonary fibrosis by regulating endothelium tight junction

27 Oct 2021

Abstract excerpt

Purpose Radiation-induced pulmonary fibrosis (RIPF) is a major side effect after radiotherapy for thoracic malignancies. However, rare anti-RIPF therapeutics show definitive effects for treating this disease. Ubiquitin-specific peptidase 11 (USP11) has been reported to promote transforming growth factor β (TGFβ) signaling which plays an essential role underlying RIPF. Herein, we explored the role of USP11 on...

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PMID: 34705600
DOI: 10.1080/09553002.2022.1998711

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