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CCDC89 is required for optimal sperm motility and male fertility in mammals

18 Jun 2025

Abstract excerpt

STUDY QUESTION: What is the role of coiled-coil domain-containing protein 89 (CCDC89) in mammalian male fertility? SUMMARY ANSWER: The presence of CCDC89 is required for normal sperm motility and therefore optimal male fertility in mice, while CCDC89 variants affected spermatogenesis in both mice and humans. WHAT IS KNOWN ALREADY: Coiled-coiled domain-containing proteins play a variety of roles in biological...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 40591933
DOI: 10.1093/humrep/deaf126

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