Article
Cryptorchidism: Novel genetic insights into CCDC149 mutations.
Andrology - 1 Jul 2026
Du Shengrong, Xu Shan, Yang Lei, Ye Yan, Wu Yuhan, Xiao Ziyun, Dong Xiuqing, Yao Wenliang, Li Hua
Abstract excerpt
BACKGROUND: Cryptorchidism, characterized by the failure of one or both testes to descend into the scrotum, is a common congenital condition that can lead to infertility and increased risk of testicular cancer. CCDC149, a coiled-coil domain-containing protein, has been implicated in various developmental processes, but its role in the male reproductive system remains unexplored. OBJECTIVE: This study aims to...
Topics
- Male
- Cryptorchidism
- Animals
- Humans
- Mice, Knockout
- Mice
- Mutation
- Child
- Exome Sequencing
- Testis
- Phenotype