Article
Novel biallelic mutations in TTC29 cause asthenoteratospermia and male infertility.
Molecular genetics & genomic medicine - 1 Dec 2022
Dai Siyu, Liang Yan, Liu Mohan, Yang Yanting, Liu Hongqian, Shen Ying
Abstract excerpt
BACKGROUND: Multiple morphological abnormalities of the sperm flagella (MMAF), which is characterized as asthenoteratospermia involving absent, short, bent, coiled, and/or irregular-caliber flagella, is a rare recessive inherited disorder associated with male infertility. To date, genetic causes of MMAF cases are not fully explored. METHODS: Whole-exome sequencing was conducted to identify pathogenic variants in...
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