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Article

Analysis of 470,000 exome-sequenced cases and controls fails to identify any genes impacting risk of developing affective disorder.

Acta neuropsychiatrica - 30 Jun 2025

Curtis David

Abstract excerpt

OBJECTIVE: A previous analysis of 200,000 exome-sequenced UK Biobank participants using weighted burden analysis of rare, damaging variants failed to identify any genes associated with risk of affective disorder requiring specialist treatment. Exome-sequence data has now been made available for the remaining 270,000 participants and a two-stage process was applied in order to test for association in this second...

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PMID: 40583353
DOI: 10.1017/neu.2025.10025
PMCID: PMC13130275

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