Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A myostatin inhibitory antibody combined with insulin, partially rescues the musculoskeletal phenotype of female insulin-deficient diabetic mice.

Frontiers in endocrinology - 1 Jan 2025

Bunn R Clay, Adatorwovor Reuben, Ray Philip D, Keeble Alexander R, Fry Christopher S, Uppuganti Sasidhar, Nyman Jeffry S, Fowlkes John L, Kalaitzoglou Evangelia

Abstract excerpt

Introduction: Type 1 diabetes is associated with deficits in both skeletal muscle and bone. Inhibition of myostatin, a negative regulator of muscle mass, was explored as a druggable target to improve the musculoskeletal phenotype associated with insulin-deficient diabetes in female mice. Methods: We investigated whether administration of an inhibitory myostatin antibody (MyoAb) in streptozotocin-induced diabetes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies
Share to Body Composition

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Experimental

Share to Diabetes Mellitus, Type 1

Share to Insulin

Share to Muscle, Skeletal

Share to Myostatin

Source

Open in PubMed Open full text

Identifiers

PMID: 40575255
DOI: 10.3389/fendo.2025.1558740
PMCID: PMC12198561

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 11 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A myostatin inhibitory antibody combined with insulin, partially rescues the musculoskeletal phenotype of female insulin-deficient diabetic mice.PMID 40575255Read ↗

Metabolic Functions of Myostatin and GDF11Semantic proximity Read ↗

Myostatin Inhibitors: Panacea or Predicament for Musculoskeletal Disorders?Semantic proximity Read ↗

Mouse models of type 1 diabetes and their use in skeletal researchSemantic proximity Read ↗

The Function of Myostatin in Ameliorating Bone Metabolism Abnormalities in Individuals with Type 2 Diabetes Mellitus by ExerciseSemantic proximity Read ↗

Implications of Skeletal Muscle Extracellular Matrix Remodeling in Metabolic Disorders: Diabetes PerspectiveSemantic proximity Read ↗

Biomechanical Stimulation of Muscles Influences Bone Phenotype by Modulating Myokine SecretionSemantic proximity Read ↗

Myostatin: a modulator of skeletal-muscle stem cellsSemantic proximity Read ↗

Therapeutic applications and challenges in myostatin inhibition for enhanced skeletal muscle mass and functionsSemantic proximity Read ↗

The impact of SGLT2 inhibitors, compared with insulin, on diabetic bone disease in a mouse model of type 1 diabetes.Semantic proximity Read ↗

A VLP-based immunogen that elicits selective anti-Myostatin antibodies, enhances muscle mass and strength, and reduces adipositySemantic proximity Read ↗

The growth factor myostatin, a key regulator in skeletal muscle growth and homeostasis.Semantic proximity Read ↗

Myostatin deficiency partially rescues the bone phenotype of osteogenesis imperfecta model mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.