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Critical role of guanylate binding protein 5 in tumor immune microenvironment and predictive value of immunotherapy response

30 Sept 2022

Abstract excerpt

Background: The guanylate-binding proteins (GBPs) are the latest potential targets of immunotherapy. However, the role of GBP5 in pan-cancer, including colorectal cancer (CRC), remains unclear. This study aims to explore the effect of GBP5 on immunity in pan-cancer. Methods: Based on the RNA sequencing data of 33 cancers obtained from The Cancer Genome Atlas, we analyzed the clinical significance of GBPs and...

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PMID: 36246628
DOI: 10.3389/fgene.2022.984615

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