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Article

Single-cell eQTL analysis identifies genetic variation underlying metabolic dysfunction-associated steatohepatitis.

Nature genetics - 1 Jul 2025

Hong Sung Eun, Mun Seon Ju, Lee Young Joo, Yoo Taekyeong, Suh Kyung-Suk, Kang Keon Wook, Son Myung Jin, Kim Won, Choi Murim

Abstract excerpt

Metabolic dysfunction-associated steatotic liver disease (MASLD) is increasingly recognized for its medical and socioeconomic impacts, driven by diverse genetic and environmental factors. Here, to address the urgent need for individually tailored therapies, we show results from single-cell expression quantitative trait locus (sc-eQTL) analysis on liver biopsies from 25 patients with MASLD and 23 controls. This...

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PMID: 40562914
DOI: 10.1038/s41588-025-02237-8

Genes

EFHD1
FOXO1

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