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ETMR stem-like state and chemo-resistance are supported by perivascular cells at single-cell resolution

25 Jun 2025

Abstract excerpt

Abstract Embryonal tumor with multilayered rosettes (ETMR) is a lethal embryonal brain tumor entity. To investigate the intratumoral heterogeneity and cellular communication in the tumor microenvironment (TME), we analyze in this work single-cell RNA sequencing of about 250,000 cells of primary human and murine ETMR, in vitro cultures, and a 3D forebrain organoid model of ETMR, supporting the main findings with...

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PMID: 40562749
DOI: 10.1038/s41467-025-60442-9

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