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Molecular Insights into Outer Dynein Arm Defects in Primary Ciliary Dyskinesia: Involvement of ZMYND10 and GRP78.

Cells - 17 Jun 2025

Erdem İlker Levent, Kaya Zeynep Bengisu, Atilla Pergin, Emiralioğlu Nagehan, Eylem Cemil Can, Nemutlu Emirhan, Özçelik Uğur, Büyükşahin Halime Nayır, Daniş Ayşenur, Karakoç Elif

Abstract excerpt

BACKGROUND: Primary ciliary dyskinesia (PCD) is a rare genetic disorder characterized by recurrent sinopulmonary infections due to motile cilia defects. The disease is genetically heterogeneous, with abnormalities in structural ciliary proteins. Zinc finger MYND-type containing 10 (ZMYND10) is essential for the assembly of outer dynein arms (ODA), with chaperones like Glucose-regulated protein 78 (GRP78)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40558543
DOI: 10.3390/cells14120916
PMCID: PMC12190660

Genes

DNAH5
ZMYND10
CTCF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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Molecular Insights into Outer Dynein Arm Defects in Primary Ciliary Dyskinesia: Involvement of ZMYND10 and GRP78.PMID 40558543Read ↗

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Proteomic and structural comparison between cilia from primary ciliary dyskinesia patients with a DNAH5 defectSemantic proximity Read ↗

Mutations in ZMYND10, a gene essential for proper axonemal assembly of inner and outer dynein arms in humans and flies, cause primary ciliary dyskinesia.Semantic proximity Read ↗

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