Article
Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice.
Frontiers of medicine - 1 Oct 2023
Wang Rongchun, Yang Danhui, Tu Chaofeng, Lei Cheng, Ding Shuizi, Guo Ting, Wang Lin, Liu Ying, Lu Chenyang, Yang Binyi, Ouyang Shi, Gong Ke, Tan Zhiping, Deng Yun, Tan Yueqiu, Qing Jie, Luo Hong
Abstract excerpt
Primary ciliary dyskinesia (PCD) is a congenital, motile ciliopathy with pleiotropic symptoms. Although nearly 50 causative genes have been identified, they only account for approximately 70% of definitive PCD cases. Dynein axonemal heavy chain 10 (DNAH10) encodes a subunit of the inner arm dynein heavy chain in motile cilia and sperm flagella. Based on the common axoneme structure of motile cilia and sperm...
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