Article
CD38-Targeting Peptide Vaccine Ameliorates Aging-Associated Phenotypes in Mice.
Aging cell - 1 Sept 2025
Yu Shangcheng, Li Zhiqiang, Tang Yuxiang, Chen Yuling, Ma Yingying, Du Kunlin, Zong Zhaoyun, Feng Kangze, Wei Yali, Chen Limeng, Deng Haiteng
Abstract excerpt
Antiaging vaccines have recently been found to elicit long-term benefits in slowing the aging process. Meanwhile, high CD38 expression in organs is an aging characteristic contributing to a decreased NAD+/NADH ratio. Thus, in the current study, we systematically investigate the effects of a CD38-targeting peptide vaccine (CD38-vaccine) on aging-associated phenotypes in mice. The CD38-vaccine induces a robust...
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