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Article

Mendelian randomization analysis does not reveal a causal association between genetic liability to chronic pain and autism spectrum disorder.

Journal of psychosomatic research - 1 Aug 2025

Chen Zheng, Yang Qiaoyun, Zhang Shuibing, Yang Dae-Jung, Peng Tuochao

Abstract excerpt

OBJECTIVE: Although observational studies suggest potential comorbidities between chronic pain (CP) and autism spectrum disorder (ASD), causal relationship remains unclear. This study aimed to investigate the causal association between genetic liability to CP and ASD using a bidirectional Mendelian Randomization (MR) analysis. METHODS: Genome-wide association summary-level data for CP and ASD were sourced from...

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Identifiers

PMID: 40554134
DOI: 10.1016/j.jpsychores.2025.112189

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CP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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