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Ciliary biology intersects autism and congenital heart disease

15 Jun 2025

Abstract excerpt

Autism spectrum disorder (ASD) and congenital heart disease (CHD) frequently co-occur, yet the underlying molecular mechanisms of this comorbidity remain unknown. Given that children with CHD are identified as newborns, understanding which CHD variants are associated with autism could help select individuals for early intervention. Autism gene perturbations commonly dysregulate neural progenitor cell (NPC)...

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PMID: 40552535
DOI: 10.1242/dev.204295

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