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Article

Genetic drivers of congenital cardiac fibrosis.

Communications biology - 27 May 2026

Zeigler Angela C, Touma Marlin

Abstract excerpt

Cardiac fibrosis in congenital heart disease (CHD) is associated with poor outcomes, but the genetic risk factors have not been clearly outlined. This review details genes important for regulation of normal cardiac development or fibrosis, particularly cilia-related genes. Specific CHD pathologies have different patterns of fibrosis, likely from interaction between genetic mutations and environmental factors....

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Share to Fibrosis
Share to Genetic Predisposition to Disease
Share to Heart Defects, Congenital

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42203827
DOI: 10.1038/s42003-026-10353-2
PMCID: PMC13216529

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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