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Article

A molecular signature predicts hematologic evolution in polycythemia vera patients.

Leukemia - 1 Aug 2025

Mansier Olivier, Lippert Eric, Benajiba Lina, Ranta Dana, Girodon François, Ianotto Jean-Christophe, Chauveau Aurélie, Roy Lydia, Boyer Françoise, Médiavilla Clémence, Tavitian Suzanne, Divoux Marion, Fanet Mélinda, Sloma Ivan, De Mas Véronique, Denis Guillaume, Nunes Gomes Christopher, Calmettes Claire, Barraco Fiorenza, Huet Sarah, Vacheret Fabienne, Mercier Mélanie, Parry Anne, Legros Laurence, Soret-Dulphy Juliette, Argentin Joris, Sureau Léa, Verger Emmanuelle, Orvain Corentin, Riou Jérémie, Kiladjian Jean-Jacques, Cassinat Bruno, Ugo Valérie, Luque Paz Damien

Abstract excerpt

Genetic analyses have been included in scoring systems to improve the prognostic stratification of hematologic malignancies. Until now, molecular risk scores have not been included into the practical management of patients with polycythemia vera (PV). In this work, we studied 439 PV patients recruited from 15 French centers and described their mutational landscape using high-throughput sequencing. We detected an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40533498
DOI: 10.1038/s41375-025-02660-0
PMCID: PMC12310540

Genes

ASXL1
IDH1
NFE2
SRSF2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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