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Article

Mutation-enhanced international prognostic systems for essential thrombocythaemia and polycythaemia vera.

British journal of haematology - 1 Apr 2020

Tefferi Ayalew, Guglielmelli Paola, Lasho Terra L, Coltro Giacomo, Finke Christy M, Loscocco Giuseppe G, Sordi Benedetta, Szuber Natasha, Rotunno Giada, Pacilli Annalisa, Hanson Curtis A, Ketterling Rhett P, Pardanani Animesh, Gangat Naseema, Vannucchi Alessandro M

Abstract excerpt

Survival prediction in essential thrombocythaemia (ET) and polycythaemia vera (PV) is currently based on clinically-derived variables; we examined the possibility of integrating genetic information for predicting survival. To this end, 906 molecularly-annotated patients (416 Mayo Clinic; 490 University of Florence, Italy), including 502 ET and 404 PV, were recruited. Multivariable analysis identified spliceosome...

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PMID: 31945802
DOI: 10.1111/bjh.16380

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