Article
Identifying the genomic landscape of EGFR-mutant lung cancers with central nervous system metastases.
Annals of oncology : official journal of the European Society for Medical Oncology - 1 Oct 2025
Wilcox J A, Jeng M Y, Tischfield S, Sui J S Y, Nemirovsky D, Heller G, Choudhury N J, Ross J S, Rudin C M, Riely G J, Kris M G, Donoghue M, Boire A A, Yu H A
Abstract excerpt
BACKGROUND: Despite the intracranial efficacy of osimertinib, central nervous system (CNS) metastases remain a major cause of morbidity and mortality in EGFR-mutant non-small-cell lung cancer (NSCLC). The genomic drivers of CNS dissemination are poorly understood. PATIENTS AND METHODS: We analyzed the clinicogenomic features of patients with EGFR-mutant NSCLC receiving first-line osimertinib with extracranial...
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