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Early-to-mid stage idiopathic Parkinson’s disease shows enhanced cytotoxicity and differentiation in CD8 T-cells in females

20 Nov 2023

Abstract excerpt

Abstract Neuroinflammation in the brain contributes to the pathogenesis of Parkinson’s disease (PD), but the potential dysregulation of peripheral immunity has not been systematically investigated for idiopathic PD (iPD). Here we showed an elevated peripheral cytotoxic immune milieu, with more terminally-differentiated effector memory (TEMRA) CD8 T, CD8 + NKT cells and circulating cytotoxic molecules in fresh...

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CAR-T cell therapy research
Neuroinflammation and Neurodegeneration Mechanisms
Nuclear Receptors and Signaling

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37985656
DOI: 10.1038/s41467-023-43053-0

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